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The Substance

"If you follow the instructions, what could go wrong?"

PG-13 2 hours 21 minutes. 2024-09-07 Horror, Science Fiction,

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

DirectorCoralie Fargeat

Cast & Crew

Demi Moore

as Elisabeth

Margaret Qualley

as Sue

Dennis Quaid

as Harvey

Edward Hamilton-Clark

as Fred

Gore Abrams

as Oliver

Oscar Lesage

as Troy

Christian Erickson

as Man at Diner

Robin Greer

as Male Nurse

Tom Morton

as Doctor

Hugo Diego Garcia

as Diego - Boyfriend

Daniel Knight

as Casting Director

Jonathon Carley

as Assistant Casting Director

Jiselle Henderkott

as Girl Auditioning / New Year's Eve Show Dancer

Akil Wingate

as TV Host

Vincent Colombe

as Man in Suit #1 - Harvey's Office

Billy Bentley

as Man in Suit #2

Lennard Ridsdale

as Man in Suit #3

Jordan Ford Silver

as Assistant Director - Pump It Up Show

Oscar Salem

as 2nd Assistant Director - Pump It Up Show

Viviane Bossina

as Sue's Assistant

Matthew Luret

as Floor Runner

Jana Bittnerová

as Maria

Olivier Raynal

as Alan - 2nd Agent

Tiffany Hofstetter

as Stylist

Nicolas Royer

as Guy in the Elevator

Nathan Rippy

as Assistant Director - New Year's Eve Show

Manon Arizmendi

as Little Girl - New Year's Eve Show

Virginie Kotlinski

as Mother - New Year's Eve Show

Brett Gillen

as Director of Photography - New Year's Eve Show

Charlotte Marquardt

as Screaming Woman

Léa Hengl

as Screaming Woman

Gaëlle Raymond

as Screaming Woman

Claire Lemaire

as Screaming Woman

Lila Boughoufala

as Screaming Woman

Aurélien Lorgnier

as Screaming Man

Ivan Sellier

as Screaming Man

Philip Schurer

as Screaming Man

Christian Bourmier

as Shareholder

Martin Graham

as Shareholder

Christian Bordeleau

as Shareholder

Patrick Hamel

as Shareholder

Didier Dhondt

as Shareholder

Jacques-Yves Dorges

as Shareholder

Jean-Claude Matthey

as Shareholder

Olivier Jarcin

as Shareholder

Jean-Luc Magneron

as Shareholder

Charlotte Murray

as Allison - Diner Waitress

Aaron Kahn

as Greeting Person

Gabriela Arnon

as Greeting Person

Nancy Josephson Lahoussine

as Greeting Person

Andrew Eldridge

as Greeting Person

Denise Powers

as Greeting Person

Bryan Jones

as Greeting Person

Adam Carage

as Happy Birthday Person

Maria McClurg

as Happy Birthday Person

Andrew Desmond

as Happy Birthday Person

Rebecca Lafont

as Happy Birthday Person

Laura Puech

as Isabella

Ryan Chidester

as Stagehand

Céline Vogt

as Elisabeth (Young) - Walk of Fame

Yannick Guérin

as Clumsy Burger Guy - Walk of Fame

Jean Miel

as Worker Walk of Fame

Paul Descoings

as Worker Walk of Fame

Benoit Lévêque

as Worker Walk of Fame

Arthur Molinet

as Cocktail Bartender

Manon Sachot

as Cocktail Lounge Couple

Bastien Jorelle

as Cocktail Lounge Couple

Kelly Hoarau

as Female Assistant - Towel

Michel Juskiewicz

as George - Harvey's Friend

Louise Greggory

as Restaurant Waitress

Christophe Sartirano

as Guy Looking at Sue

Florent Torres

as Guy Looking at Sue

Romain Caldeira

as Billboard Technician

Barthelemy Thomas

as Billboard Technician

Axel Baille

as Photographer

Ashley Lambert

as Additional Voices (voice)

Ranjani Brow

as Additional Voices (voice)

Chase Fein

as Additional Voices (voice)

Shane Sweet

as Additional Voices (voice)

William Calvert

as Additional Voices (voice)

Michael Corbett

as Additional Voices (voice)

Stephen Apostolina

as Additional Voices (voice)

Yann Bean

as The Substance (voice)

Audjyan Alcide

as Pump It Up Show Dancer

Jonathan Jenvrin

as Pump It Up Show Dancer

Mimi Maury

as Pump It Up Show Dancer

Amelye Solange

as Pump It Up Show Dancer

Kévin Table

as Pump It Up Show Dancer

Laura Boera

as Sparkle Your Life Show Dancer

Cissy Duc

as Sparkle Your Life Show Dancer

Sophie Mercier

as Sparkle Your Life Show Dancer

Marie Valton

as Sparkle Your Life Show Dancer

Katrina Budzynski

as New Year's Eve Show Dancer

Alicia Maury

as New Year's Eve Show Dancer

Megane Adamik

as New Year's Eve Show Dancer

Annalisa Pagnotta

as New Year's Eve Show Dancer

Maelle Dantigny

as New Year's Eve Show Dancer

Aleksandra Fontaine Kedzierska

as New Year's Eve Show Dancer

Pauline Sagetat

as New Year's Eve Show Dancer

Agustina Fitzsimons

as New Year's Eve Show Dancer

Elena Shcheglova

as New Year's Eve Show Dancer

Eve Marchant

as New Year's Eve Show Dancer

Lola Donati

as New Year's Eve Show Dancer

Kate Matthews

as New Year's Eve Show Dancer

Ophélie Jonard

as New Year's Eve Show Dancer

Pauline Richard

as New Year's Eve Show Dancer

Laureen Cappelliez

as New Year's Eve Show Dancer

Daria Panchenko

as New Year's Eve Show Dancer

Delphine Beaulieu

as New Year's Eve Show Dancer

Victoria Brun

as New Year's Eve Show Dancer

Cara Chapman

as New Year's Eve Show Dancer

Katharine Matthews

as New Year's Eve Show Dancer

Alexandra Faget

as New Year's Eve Show Dancer

Clémence Juville

as New Year's Eve Show Dancer

Margot L'Entete

as New Year's Eve Show Dancer

Hillary Sukhonos

as New Year's Eve Show Dancer

Matthew Géczy

as Bob Haswell (uncredited)

Namory Bakayoko

as Silhouette (uncredited)

Gregory Defleur

as Happy Birthday Person (uncredited)

Coralie Fargeat

as (uncredited)